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Cinchonism



Cinchonism Causes


The main cause is quinine overdose.


Cinchonism Definition


Cinchonism is defined as a pathological disorder involving a prolonged or excessive use of a white-crystalline alkloid component called quinine, or its natural supplier -the cinchona bark. Quinine is primarily used for treating resistant malaria, night-time muscle cramps, as well as can act as an “abortifacient”. It can harmfully affect nearly all body system, the most common being cinchonism or quinine poisoning.


Cinchonism Diagnosis


The disorder is diagnosed through blood test for blood sugar, blood count, renal function tests, urinalysis, prothrombin time, and electrolytes. Periodic examinations of the eyes must have visual acuity test. Other methods for diagnosis include electrooculogram, color testing, and dark adaptations.


Cinchonism Symptoms and Signs


Mild cinchonism symptoms include vasodilation, headache, sweating, tinnitus, nausea, dizziness, hearing impairment, color perception disturbance, and blurred vision. More severe manifestations include diarrhea, vomiting, deafness, abdominal pain, blindness, and cardiac rhythm disturbances.


Cinchonism Treatment


Most symptoms can be reversed and resolved through discontinuing the use of quinine. Mild symptoms typically resolve promptly; however, severe symptoms may persist for several months. Quinine is quickly absorbed, so any attempts to take out quinine in the stomach through gastric lavage might not be effectual. Multiple-dose of activated charcoal has shown to reduce concentrations of plasma quinine.


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