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Factor V Deficiency

Factor V Deficiency Causes

Factor V deficiency is very uncommon, and may be caused through inheritance of a defective gene, particularly Factor V gene. It can also be caused through acquiring antibody that hinders the normal function of Factor V. A Factor V inhibitor can also be obtained after delivery, after surgery, or with certain cancers and autoimmune diseases, or in patients that are being treated with a particular kind of fibrin glue, coming from an unknown source.

Factor V Deficiency Definition

Factor V deficiency is a hereditary disorder in which there is an anomalous blood coagulation, resulting from a deficiency in a plasma protein called Factor V. Factor V functions as an enzyme cofactor; the deficiency will lead to a tendency for hemorrhage, while some mutations influence thrombosis.

Factor V Deficiency Diagnosis

Factor V deficiency can be diagnosed through physical examination and tests. Tests and exams that are done may include Factor V assay, analysis of bleeding time, prothrombin time, thromboplastin time, and thrombin time.

Factor V Deficiency Symptoms and Signs

Symptoms of the disease include nosebleeds, gum bleeding, excessive bruising, skin bleeding, excessive or prolonged blood loss with trauma or injury, extreme menstrual bleeding, and umbilical stump bleeding.

Factor V Deficiency Treatment

The deficiency can temporarily be corrected through the administration of fresh plasma infusions, given every day during bleeding episodes or following surgery.

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