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Familial Adenomatous Polyposis

Familial Adenomatous Polyposis Causes

Familial adenomatous polyposis is caused by the gene mutations of APC or adenomatous polyposis coli. It is also inherited in a ‘dominant' manner, so that a patient has fifty percent chances of transmitting defective gene. APC gene mutations lead to non-functioning protein, which disrupts cell proliferation balance and death of cell.

Familial Adenomatous Polyposis Definition

Familial adenomatous polyposis is a common genetic disorder that can lead to cancer of the colon if it is left undetected. Affected individuals develop countless ‘adenomatous colorectal polyps' in the rectum or colon, particularly during their teenage years and twenties. The polyps aren't cancerous, but due to their numerous quantities, there's greater chance that a number will go through mutation and trigger cancer development.

Familial Adenomatous Polyposis Diagnosis

Familial adenomatous polyposis is supposed after a complete history and examination. Diagnosis of FAP also requires genetic testing. The upper intestine can also be examined through endoscopic surveillance, as patients can also build up polyps there.

Familial Adenomatous Polyposis Symptoms and Signs

The condition may be symptomatic, particularly if an affected child is being observed at an early age due to positive history of family. Symptoms in patients may include tummy pain, rectal bleeding, bony growths, and symptoms associated with cancer.

Familial Adenomatous Polyposis Treatment

Because colorectal cancer is sure in affected individuals, the majority of patients opt for optional colon removal before the cancer develops. However, these patients will need long-term follow-up for other cancer developments.

Drugs used for treatment of Familial Adenomatous Polyposis


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