Hodgkin's disease
Hodgkin's disease Causes
The exact cause of Hodgkin's disease is not known. 5 types pf Hodgkin's disease are recognized ? all among a group of cancers called lymphomas ? cancers of the lymphatic system. The lymphatic system includes the lymph nodes (lymph glands), which are found throughout the body and are connected by small vessels called lymphatics. The spleen, thymus gland and bone marrow also belong to the lymphatic system.
Hodgkin's disease Definition
In Hodgkin's disease, cells in the lymphatic system develop abnormally and may spread beyond the lymphatic system. As Hodgkin's disease progresses, it compromises the body's ability to fight different infections.
Hodgkin's disease Diagnosis
A tissue sample (biopsy) of an enlarged lymph node is necessary to make the diagnosis. The pathologist searches for changes in the normal lymph node architecture and cell characteristics, including the presence of Reed-Sternberg cells. The affected lymph nodes may have only a few of these malignant cells.
Hodgkin's disease Symptoms and Signs
Hodgkin's disease symptoms may include: painless swelling of lymph nodes in the neck, armipits, or groin; persistent fatigue; fever and chills; night sweats; unexplained weight loss, as much as 10% of the total body weight; loss of appetite; and itching.
Hodgkin's disease Treatment
Treatment options include radiation, chemotherapy (ABVD, BEACOPP, COPP/ABVD, Stanford V, and MOPP), and bone marrow transplant.