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Howel-Evans syndrome

Howel-Evans syndrome Causes

Hereditary keratoderma runs in families and is passed down or from one or both parent(s) to their children while acquired keratoderma is not inherited and occurs as a result of a change in the health or the environment of the affected person

Howel-Evans syndrome Definition

Howel-Evans syndrome is a very rare condition in which the skin of the palms of the hands, and soles of the feet, are affected (hyperkeratosis). The effects on the palms and soles is called tylosis, and in Howel-Evans syndrome, there is a high risk for oesophageal cancer, particularly squamous cell carcinoma.

Howel-Evans syndrome Symptoms and Signs

Some symptoms of Howel-Evans syndrome include hyperkeratosis of palms, hyperkeratosis of the soles of the feet, and esophageal cancer.

Howel-Evans syndrome Treatment

The skin is treated with a keratolytic (such as salicylic acid) to dissolve the excess skin, and systemic treatment with retinoids (derivatives of Vitamin A) may be administered.

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