Mastocytosis
Mastocytosis Causes
Mastocytosis results when too many mastocytes and CD34+ mast cell precursors exists, which the body cannot handle.
Mastocytosis Definition
Mastocytosis is a disorder that results when too many mast cells, called mastocytes, and CD34+ mast cell precursors exist in the body. It has many types and may be experienced by children and adults.
Mastocytosis Diagnosis
In the case of urticaria pigmentosa or cutaneous mastocytosis, doctors examine a skin sample with distinct dark-brown and fixed lesions to confirm the existence of the disorder. In a systemic mastocytosis, doctors examine a sample from an organ like the bone marrow to examine whether there is an increase in mast cells. The disorder may also be determined through presence of high levels of certain mast-cell chemicals and proteins in the blood or urine.
Mastocytosis Symptoms and Signs
In rare cases, the body's immune system is affected showing symptoms characteristic to allergies like itching, abdominal cramps, and anaphylaxis. The patient may also experience skin lesions, bone/muscle pain, nausea and vomiting or, very low blood pressure and faintness
Mastocytosis Treatment
Currently, mastocytosis has no cure but some medicines exist only treat the symptoms. Such medicines include Antihistamines, Leukotriene, or mast cell stabilizers. However, only Cromolyn Sodium Oral Solution is approved by the U.S. FDA for treating mastocytosis. Clinical trials that test stem cell transplants are also forms of treatment. Some patients also join support groups for emotional therapy.