Mastocytosis
Mastocytosis Causes
Causes of underlying conditions the possible cause mastocytosis includes: Cancer and Blood disorder.
Mastocytosis Definition
Mastocytosis is a group of unusual disorder of both children and adults caused by the presence of too many mast cells (mastocytes) and CD34+ mast cell precursors in a person's body.
Mastocytosis Diagnosis
Doctors can diagnose urticaria pigmentosa (cutaneous mastocytosis, see below) by seeing the characteristic lesions that are dark-brown and fixed. A tiny skin sample (biopsy) may help confirm the diagnosis.
Mastocytosis Symptoms and Signs
In some rare cases chemicals released by mast cells cause changes in the immune system leading to typical allergy symptoms such as: Itching, Abdominal cramping, Anaphylaxis (shock from allergic or immune causes), When too many mast cells exist in a person's body, the additional chemicals can cause: Skin lesions, Abdominal discomfort, Episodes of very low blood pressure (including shock) and faintness, Bone or muscle pain, Nausea and vomiting
Mastocytosis Treatment
There is currently no cure for mastocytosis. However, there are a number of medicines to help treat the symptoms of mastocytosis: Antihistamines block receptors targeted by histamine released from mast cells. Both H1 and H2 blockers can be helpful. Leukotriene antagonists block receptors targeted by leukotrienes removed from mast cells. A mast cell stabilizer helps prevent mast cells from releasing their chemical contents. Cromolyn Sodium Oral Solution (Gastrocrom / Cromoglicate) is the only one medicine specifically approved by the U.S.FDA for the treatment of mastocytosis.