Monoclonal gammopathy of undetermined significance
Monoclonal gammopathy of undetermined significance Causes
Some theories applicable to the pathogenesis of multiple myeloma may also be valid for MGUS but the cause remains unknown.
Monoclonal gammopathy of undetermined significance Definition
Monoclonal gammopathy of undetermined significance (MGUS) or benign monoclonal gammopathy is a condition in which a low or non-quantifiable level of a monoclonal paraprotein is detected in the blood by means of protein electrophoresis. Undetermined in the term may also be replaced with unknown or uncertain.
Monoclonal gammopathy of undetermined significance Diagnosis
A blood test for another condition usually makes way for the discovery of the disease. The test is actually called serum proteins electrophoresis (SPEP) in which blood proteins are separated into five parts and can show abnormalities. If MGUS is detected, further tests such as blood tests, x-rays, and a bone marrow test may be conducted.
Monoclonal gammopathy of undetermined significance Symptoms and Signs
MGUS does not usually cause symptoms and is usually discovered by accident during laboratory tests are conducted for other purposes. The monoclonal antibody however can bind to nerves and lead to numbness, tingling, and weakness.
Monoclonal gammopathy of undetermined significance Treatment
MGUS does not require treatment but doctors may suggest frequent check-ups to monitor a patient's health in order to avoid the development of more serious symptoms.