Multiple endocrine neoplasia type 2
Multiple endocrine neoplasia type 2 Causes
The gain-of-function variant of a RET gene generally results in MEN2. MEN2 can also be inherited and transmitted in an autosomal dominant pattern. There are some cases however that result from spontaneous new mutations in the RET gene, which means it may occur even to those with no family history of the disorder.
Multiple endocrine neoplasia type 2 Definition
Multiple endocrine neoplasia type 2 (MEN2) is a group of medical disorders linked with tumors that maybe benign or malignant, of the endocrine system. Generally occurring in endocrine organs such as thyroid, parathyroid, and adrenals, tumor/s may also occur in endocrine tissues and not in a classical endocrine organ. MEN2 itself is a sub-type of multiple endocrine neoplasia (MEN).
Multiple endocrine neoplasia type 2 Diagnosis
The disease is clinically diagnosed by the occurrence of two or more specific endocrine tumors in a single individual or in close relatives.
Multiple endocrine neoplasia type 2 Symptoms and Signs
Pheochromocytoma may develop among people with MEN2 and can cause a dangerously high blood pressure. A form of thyroid cancer called medullary thyroid carcinoma is the most common sign of MEN2. Hyperparathyroidism also occurs among affected person with MEN2A.
Multiple endocrine neoplasia type 2 Treatment
Surgery is performed to treat MEN2. Prostaglandin inhibitors are also utilized as a preoperative medical treatment in order to alleviate the diarrhea that may be associated with medullary thyroid cancer.