Myeloperoxidase Deficiency

Myeloperoxidase Deficiency Causes

It is quite difficult to interpret the genetics of this disorder based on varying familial expressions. Among 17 reported cases, autosomal recessive inheritance had been proved in 7 cases and had also been considered likely among the 8 others due to the pre-existence of 2 or 3 deficient individuals within the family.

Myeloperoxidase Deficiency Definition

Myeloperoxidase deficiency is considered a common genetic disorder which is characterized by a deficiency in the quantity of enzyme myeloperoxidase or its lack of functionality in the human body. This enzyme can usually be found in some types of phagocytic immune cells, the polymorphonuclear leukocytes in particular. Myeloperoxidase deficiency typically has no distinct signs of immunodeficiency among majority of affected patients. This is despite its immune deficiency presentation which is especially observed in candida albicans infections. Basically, this condition shows no specific manifestations of an immunodeficiency. The absence of major symptoms for Myeloperoxidase deficiency suggest that the role of the enzyme myeloperoxidase in immune responses might be similar with that of other mechanisms of intracellular killing of bacteria that had been phagocytosed.