Pemphigus Vulgaris
Pemphigus Vulgaris Causes
Pemphigus vulgaris is caused by the actions of our anti-bodies against Desmoglein 3.
Pemphigus Vulgaris Definition
The pemphigus vulgaris is the most common form of Pemphigus disorder. Pemphigus vulgaris results when the antibodies attack the Desmoglein 3. It causes sores originating in the mouth and making eating difficult and also uncomfortable for the sufferer. Commonly, it occurs to people who are between the ages of 40 and 60 although it can also affect other people not belonging to that age group. In rare cases though, it is linked with myasthenia gravis.
Pemphigus Vulgaris Diagnosis
Pemphigus is easily determined and diagnosed by a dermatologist basing from the extent of the lesions' appareance as well as the distribution. Diagnosis will require examination of skin sample that must be done by a dermatopathologist. The sample is taken from the blister edge which is then prepared for histopathology. It is then examined under the microscope. Definitive diagnosis will also require anti-desmoglein autoantibodies demonstration via a direct immunofluorescence focused on the skin sample. It can also be diagnosed using a sample of the patient's blood sample through the use of the ELISA technique.
Pemphigus Vulgaris Symptoms and Signs
Symptoms for pemphigus vulgaris includes sores in the mouth, loss of appetite, weight loss, and weakness among others.
Pemphigus Vulgaris Treatment
In most cases, treatment for Pemphigus is done by administering oral steroids such as prednisone. In severe cases though, intravenous gamma globulin is found to be effective. Some mild cases respond to topical steroids. A powerful cocktail combination of immune suppressant drugs is at times used to halt rapid bronchiolitis obliterans progression. The cocktail includes azathioprine, solumedrol, thalidomide, and ciclosporin. Plasmapheresis can be useful too.