Porphyria Cutanea Tarda, Sporadic Type
Porphyria Cutanea Tarda, Sporadic Type Causes
TYPE I PCT can be induced or aggravated by excessive alcohol abuse due to the oxidative damage caused to the liver cells which in turn inhibits the activity of the UROD gene. Exposure to chlorinate cyclic hydrocarbons can also lead to a decreae activity of the UROD gene.
Porphyria Cutanea Tarda, Sporadic Type Definition
Porphyria cutanea tarda (PCT), sporadic type, also known as Type I PCT, is characterized by a deficiency of the uroporphyrinogen decarboxylase (UROD) which produces an enzyme that is essential to the production of heme, a molecule vital to all organs of the body. Clinic manifestations of PCT among individuals with TYPE I PCT are usually caused by risk factors such as alcohol abuse and Hepatitis C.
Porphyria Cutanea Tarda, Sporadic Type Diagnosis
Primary diagnosis of PCT, familial can be based on the blisters and skin lesions that appear on the skin of individuals suffering from the disease. A more conclusive diagnosis of the disease, however, can only be made through laboratory testing. Persons wit PCT commonly have high levels uroporphyrinogen in their urine. It is also strongly suggested that testing for Hepatitis C and hemochromatosis be made since these conditions are closely related to PCT.
Porphyria Cutanea Tarda, Sporadic Type Symptoms and Signs
Symptoms of TYPE I PCT include blistering and erosion of the exposed areas of the skin as well as hyperpigmentation and hypertrichosis. Chronic liver problems such as hepatic fibrosis, cirrhosis and inflammation are also common among sufferers of TYPE I PCT.
Porphyria Cutanea Tarda, Sporadic Type Treatment
Proper management is essential in treating TYPE I PCT. Avoidance of avoid alcoholic beverages, iron supplements, excess exposure to sunlight, chlorinated cyclic hydrocarbons and estrogen are strongly advised.