Premature Ovarian Failure
Premature Ovarian Failure Causes
Autoimmune disorders and genetic disorders such as Turner syndrome and Fragile X syndrome may cause POF. Chemotherapy and radiation therapy for cancer patients may also cause ovarian failure. Other risk factors include having pelvic or ovarian surgery earlier in life. Many cases of POF though have indeterminable causes.
Premature Ovarian Failure Definition
Premature Ovarian Failure (POF) is a condition characterized by the loss of the function of the ovaries before the age of 40. It is also known as primary ovarian insufficiency. In the U.S., approximately 150,000 women, or 1-4% of the total population, is suffering from POF.
Premature Ovarian Failure Symptoms and Signs
Women with POF suffer from infertility and decreased bone density or osteoporosis. Other health implications include increased risk of heart disease, hypothyroidism, Addison's disease and other autoimmune disorders.