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SAPHO Syndrome

SAPHO Syndrome Definition

SAPHO syndrome encompasses a range of chronic inflammatory bone diseases usually associated with skin changes.

SAPHO Syndrome Symptoms and Signs

In general, SAPHO syndrome disorders share common radiologic, clinical, and pathologic characteristics, all involving the bone, skin, and joints. Classic presentations of SAPHO syndrome can be summarized by its eponym, meaning: Synovitis (or inflammation of the joint lining), Acne (usually in the face and upper back), Pustulosis (inflammatory skin condition), Hyperostosis (abnormal excessive growth of bone), and Osteitis (bone inflammation).

SAPHO Syndrome Treatment

SAPHO syndrome patients are treated based on clinical symptoms. Commonly, therapy is focused on reducing the inflammation in affected tissues. Non-steroidal anti-inflammatory drugs and corticosteroid medications are prescribed. In addition, topical cold applications can also help reduce symptoms.

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