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Sezary SYndrome



Sezary SYndrome Causes


At present, there is still no known cause for the development of Sezary Syndrome.


Sezary SYndrome Definition


Sezary syndrome also referred to as Sezary's disease is a rare type of cutaneous lymphoma characterized by skin redness, leukemia and enlarged lymph nodes. It is a form of cutaneous T-cell lymphoma, which is a cancerous disease involving the skin. This is a disease marked by a great increase of the white blood cells known as T-lymphocytes.


Sezary SYndrome Diagnosis


People with lesion that do not response to normal medications are required to undergo a blood test in order to monitor the change in the level of lymphocytes in the blood. After which, a skin biopsy is often ordered to confirm diagnosis and to rule out other possible causes of the lesion.


Sezary SYndrome Symptoms and Signs


Sezary syndrome usually develops slowly within many years. Initial symptoms usually appear on the skin including skin redness, itching and often dry and dark patches on the skin. Other symptoms may include: Leukemia Enlarged lymph nodes Dystrophic nails Hair loss or balding (alopecia) Swelling


Sezary SYndrome Treatment


Early stages of Sezary syndrome might be treated with skin therapy directly on the skin like topical medications, superficial radiotherapy and phototherapy. Chemotherapy and immunotherapy are required treatments for advanced stages of the disease. A medication named Vorinostat is considered as a second-line drug for cutaneous T-cell lymphoma combined with phototherapy and chemotherapy.


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