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Sipple Syndrome



Sipple Syndrome Causes


Most cases of Sipple syndrome are pointed to result from autosomal dominant inheritance. It is rare in children and may occur any time from adolescence to old age.


Sipple Syndrome Definition


Sipple syndrome is a group of rare inherited disorders that causes the growth of tumors in several glands. It is also known as Multiple Endocrine Neoplasia Type 2. Tumors produced by this syndrome can either be benign or malignant. Sipple syndrome is a subtype of multiple endocrine Neoplasia producing tumors that generally occur in endocrine glands and sometimes in endocrine tissues.


Sipple Syndrome Diagnosis


Careful evaluation of the symptoms and underlying medical condition like the presence of tumors may lead to the diagnosis of Sipple syndrome. Specific diagnostic procedures may be carried out to confirm the diagnosis. The use of CT scan and MRI may lead to discovery of tumors developing in multiple glands.


Sipple Syndrome Symptoms and Signs


Signs and symptoms of Sipple syndrome include the following: • Pain in the abdominal region • Abdominal distension • Loss of appetite • Uneasiness • Nausea • Excessive urination • Dehydration • Rapid heart beat • Irritability • Paleness • Nervousness • Tremors • Excessive sweating • Increased blood pressure (hypertension) • Increased blood calcium level • Thyroid tumor


Sipple Syndrome Treatment


Treatment for Sipple syndrome is aimed at eliminating the tumors. Subsequent therapy should be carried out to prevent or minimized the remaining symptoms while hormone replacement therapy may be necessary when glands are surgically removed and hormone secretion is not enough.


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